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1994-10-25
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Document 2922
DOCN M94A2922
TI Progression of nervous system dysfunction in HIV; 5 year follow-up.
DT 9412
AU Hall CD; Messenheimer J; Wilkins JW; Whaley RA; Robertson WT; Radzion;
Hall MJ; Kwock S; Donovan MK; Robertson KR; AIDS Neurologic Center,
University of North Carolina, Chapel Hill; 27599.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):194 (abstract no. PB0203). Unique
Identifier : AIDSLINE ICA10/94369653
AB OBJECTIVE: To assess the degree of nervous system involvement and the
rate of progression of disease at different stages of HIV infection.
METHODS: A cohort of 133 adults has been followed for up to 5 years with
6 monthly evaluations. Evaluations include: neurologic; psychologic;
neuropsychologic; routine and quantitative EEG; brainstem auditory,
visual, somatosensory and cognitive evoked potentials; nerve conduction;
autonomic testing; magnetic resonance imaging and spectroscopy; and T
cell immune profile. RESULTS: Our 5 year follow-up continues to
substantiate declines in all parameters in the late stages of disease.
The changes were most profound in, but were not limited to, subjects
with clinical dementia. In the systemically asymptomatic stages,
statistically significant increases in latencies were found across time
for P300 cognitive and visual evoked potentials. DISCUSSION AND
CONCLUSIONS: There is a generalized decline in nervous system function
in the late stages of HIV infection, which is not limited to subjects
showing clinical dementia. Sensitive testing reveals subclinical but
definite evidence of progressive neurologic dysfunction in the
systemically asymptomatic stages of HIV infection.
DE Adult AIDS Dementia Complex/CLASSIFICATION/*DIAGNOSIS Female
Follow-Up Studies Human HIV Infections/CLASSIFICATION/*DIAGNOSIS Male
Nervous System Diseases/CLASSIFICATION/*DIAGNOSIS Neurologic
Examination Neuropsychological Tests MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).